Dominique P Germain Selected Research

agalsidase beta

12/2020	Improvement of gastrointestinal symptoms in a significant proportion of male patients with classic Fabry disease treated with agalsidase beta: A Fabry Registry analysis stratified by phenotype.
1/2020	Cardiomyopathy and kidney function in agalsidase beta-treated female Fabry patients: a pre-treatment vs. post-treatment analysis.
1/2018	Improvement of Fabry Disease-Related Gastrointestinal Symptoms in a Significant Proportion of Female Patients Treated with Agalsidase Beta: Data from the Fabry Registry.
5/2015	Ten-year outcome of enzyme replacement therapy with agalsidase beta in patients with Fabry disease.
3/2012	Anti-α-galactosidase A antibody response to agalsidase beta treatment: data from the Fabry Registry.
3/2012	Renal outcomes of agalsidase beta treatment for Fabry disease: role of proteinuria and timing of treatment initiation.
3/2010	Uneventful pregnancy outcome after enzyme replacement therapy with agalsidase beta in a heterozygous female with Fabry disease: A case report.
9/2008	Enzyme replacement therapy in Fabry disease: comparison of agalsidase alfa and agalsidase beta.
5/2008	Successful reinstitution of agalsidase beta therapy in Fabry disease patients with previous IgE-antibody or skin-test reactivity to the recombinant enzyme.
4/2008	Safety and efficacy of enzyme replacement therapy with agalsidase beta: an international, open-label study in pediatric patients with Fabry disease.

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Dominique P Germain Research Topics

Disease

67	Fabry Disease (Fabry's Disease) 11/2021 - 01/2002
7	Inborn Genetic Diseases (Disease, Hereditary) 01/2021 - 05/2003
6	Type IV Ehlers-Danlos Syndrome 01/2019 - 05/2002
5	Stroke (Strokes) 02/2020 - 01/2002
5	Chronic Kidney Failure (Chronic Renal Failure) 03/2015 - 01/2002
4	Cardiomyopathies (Cardiomyopathy) 01/2020 - 01/2002
4	Pain (Aches) 01/2016 - 01/2002
4	Renal Insufficiency (Renal Failure) 05/2015 - 01/2002
4	Disease Progression 03/2015 - 11/2010
4	Proteinuria 03/2012 - 03/2007
3	Diarrhea 12/2020 - 01/2018
3	Abdominal Pain (Pain, Abdominal) 12/2020 - 01/2018
3	Chronic Renal Insufficiency 02/2020 - 03/2007
3	Left Ventricular Hypertrophy (Ventricular Hypertrophy, Left) 12/2013 - 01/2011
2	COVID-19 11/2021 - 12/2020
2	Infections 11/2021 - 12/2020
2	Sphingolipidoses (Sphingolipidosis) 04/2019 - 01/2017
2	Gaucher Disease (Gaucher's Disease) 01/2017 - 01/2002
2	Hypertrophic Cardiomyopathy (Hypertrophic Obstructive Cardiomyopathy) 05/2015 - 01/2011
2	Heart Failure 03/2015 - 03/2007
2	Pseudoxanthoma Elasticum (Gronblad Strandberg Syndrome) 01/2015 - 05/2003
2	Rupture 10/2010 - 01/2004
2	Lysosomal Storage Diseases (Lysosomal Storage Disease) 03/2007 - 01/2006
1	Cardiomegaly (Heart Hypertrophy) 01/2020
1	X-Linked Genetic Diseases 01/2020
1	Albuminuria 01/2019
1	Neuralgia (Stump Neuralgia) 01/2019
1	Type C Niemann-Pick Disease (Niemann Pick Disease, Type C) 01/2017
1	GM2 Gangliosidoses (GM2 Gangliosidosis) 01/2017
1	Hydrops Fetalis (Fetal Edema) 01/2017
1	Refractive Errors (Refractive Error) 01/2015
1	Transient Ischemic Attack 11/2010
1	Angiokeratoma 11/2010
1	Cardiac Arrhythmias (Arrythmia) 11/2010
1	Fatigue 10/2010
1	Blood Vessel Dissection 10/2010
1	Rhinitis 04/2008
1	Fever (Fevers) 04/2008
1	Hypertrophy 03/2007
1	Glycogen Storage Disease Type IIb 03/2007
1	Glycogen Storage Disease Type II (Pompe's Disease) 03/2007
1	Inborn Errors Metabolism (Inborn Errors of Metabolism) 03/2007
1	Myocardial Infarction 10/2002
1	Metabolic Diseases (Metabolic Disease) 01/2002

Drug/Important Bio-Agent (IBA)

27	GalactosidasesIBA 01/2021 - 03/2007
19	EnzymesIBA 01/2020 - 01/2002
19	alpha-Galactosidase (Beano)IBA 06/2017 - 01/2002
13	globotriaosylceramide (globotriosylceramide)IBA 01/2021 - 07/2005
13	GlycosphingolipidsIBA 01/2021 - 01/2002
12	agalsidase beta FDA Link 12/2020 - 03/2007
4	CreatinineIBA 01/2020 - 03/2008
4	migalastatIBA 01/2019 - 08/2016
4	Analgesics (Analgesic Drugs)IBA 01/2016 - 01/2002
3	Biomarkers (Surrogate Marker)IBA 01/2017 - 03/2007
3	Biological ProductsIBA 01/2017 - 07/2005
3	Collagen Type III (Type III Collagen)IBA 03/2004 - 05/2002
2	Proteins (Proteins, Gene)FDA Link 03/2012 - 12/2010
2	Angiotensin-Converting Enzyme Inhibitors (ACE Inhibitors)IBA 11/2010 - 10/2002
2	Gabapentin (Neurontin)FDA LinkGeneric 10/2002 - 01/2002
1	VaccinesIBA 11/2021
1	mRNA VaccinesIBA 11/2021
1	globotriaosyl lysosphingolipidIBA 01/2021
1	GlycolipidsIBA 12/2020
1	AngiotensinsIBA 12/2020
1	ReninIBA 12/2020
1	Retinaldehyde (Retinal)IBA 08/2020
1	Lysine (L-Lysine)FDA Link 01/2019
1	Glutamic Acid (Glutamate)FDA Link 01/2019
1	lysoGM1 gangliosideIBA 01/2017
1	SphingolipidsIBA 01/2017
1	GangliosidesIBA 01/2017
1	Glucosylceramidase (Glucocerebrosidase)IBA 01/2017
1	sphingosine phosphorylcholineIBA 01/2017
1	CollagenIBA 06/2012
1	cyclo(Arg-Pro) (CI 4)IBA 03/2012
1	Indicators and Reagents (Reagents)IBA 12/2010
1	Angiotensin Receptors (Angiotensin II Receptor)IBA 11/2010
1	Celiprolol (ST1396)IBA 10/2010
1	agalsidase alfaIBA 09/2008
1	Immunoglobulin E (IgE)IBA 05/2008
1	AntibodiesIBA 05/2008
1	LipidsIBA 03/2008
1	Cystatin CIBA 07/2007
1	GlycogenIBA 03/2007
1	galabiosylceramideIBA 07/2005
1	Proteoglycans (Proteoglycan)IBA 05/2003
1	Hydroxymethylglutaryl-CoA Reductase Inhibitors (HMG-CoA Reductase Inhibitors)IBA 10/2002
1	Folic Acid (Vitamin M)FDA LinkGeneric 10/2002
1	AcidsIBA 01/2002
1	HydrolasesIBA 01/2002
1	Antihypertensive Agents (Antihypertensives)IBA 01/2002

Therapy/Procedure

30	Enzyme Replacement Therapy 12/2020 - 01/2002
11	Therapeutics 01/2021 - 01/2002
4	Kidney Transplantation 03/2015 - 01/2002
2	Enzyme Therapy 11/2010 - 10/2002
1	Treatment Delay 01/2021
1	Time-to-Treatment 01/2016
1	Pain Management 01/2016
1	Slit Lamp 01/2015
1	Intravenous Infusions 05/2008